Hand, Foot, and Mouth Disease (HFMD) and chickenpox are two common illnesses that affect children. Both cause rashes and blisters, so it can be tricky for parents to know which one their child has. But knowing the difference is important. It helps you care for your child better and keep others safe. In this article, I’ll explain how to tell HFMD and chickenpox apart in simple words.
What Is Hand, Foot, and Mouth Disease (HFMD)?
HFMD is a mild virus infection caused by enteroviruses, most often Coxsackievirus A16. It mostly affects young kids under 5 years old. The name tells you where the rash usually appears — on the hands, feet, and inside the mouth.
Here’s what HFMD looks and feels like:
- Starts with a mild fever and sore throat
- Small, painful blisters or red spots inside the mouth, on the tongue, and gums
- Red spots or blisters on the palms of the hands and soles of the feet
- Sometimes, blisters appear on the buttocks or around the diaper area
- Rash usually doesn’t itch much
- Symptoms last about 7 to 10 days
- Most kids recover without problems
HFMD spreads through saliva, mucus, stool, and direct contact with blisters or contaminated surfaces. It is common in daycares and kindergartens.

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What Is Chickenpox?
Chickenpox is caused by the varicella-zoster virus. It’s very contagious and usually affects children under 12 years old, but can happen at any age. Chickenpox causes an itchy rash all over the body.
Key facts about chickenpox:
- Starts with fever, tiredness, and headache before the rash
- Red spots that turn into itchy blisters filled with fluid
- Blisters appear mostly on the face, chest, back, and scalp but can spread everywhere
- Blisters dry out and form crusty scabs in about a week
- The rash usually itches a lot
- New blisters can appear for several days, so rash spots may be in different stages at once
- Most children recover fully in 10 to 14 days
- Chickenpox spreads through coughs, sneezes, and direct contact with blisters or scabs
How to Tell the Difference Between HFMD and Chickenpox
Sometimes, HFMD and chickenpox can look similar. Both cause blisters and rashes. Here are some simple ways to tell which one your child might have:
| Feature | HFMD | Chickenpox |
|---|---|---|
| Rash location | Hands, feet, mouth, sometimes buttocks | Starts on face, chest, back; spreads all over |
| Rash appearance | Small, painful blisters; red spots | Itchy, fluid-filled blisters; can scab over |
| Mouth sores | Common and painful | Rare; usually no mouth sores |
| Itching | Mild or none | Severe itching |
| Fever timing | Starts before rash | Starts before rash, can be higher |
| Duration | About 7-10 days | About 10-14 days |
| Contagious period | While blisters and fever last | From 1-2 days before rash until blisters crust |
| Age group | Mostly under 5 years | Mostly under 12 years |
Why Knowing the Difference Matters
Knowing which illness your child has helps in these ways:
- Care: HFMD needs pain relief for mouth sores and hydration. Chickenpox needs itching relief and monitoring for infection.
- Prevention: Both spread easily, but chickenpox can be prevented with a vaccine.
- School and daycare: Knowing the illness helps decide when your child can safely return.
- When to see a doctor: Chickenpox can sometimes cause complications. HFMD is usually mild but watch for dehydration.

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How to Care for a Child with HFMD
- Give plenty of fluids to prevent dehydration.
- Offer soft, cool foods like yogurt, smoothies, or mashed potatoes.
- Use pain relievers like acetaminophen to ease fever and mouth pain.
- Keep the child’s nails trimmed to prevent scratching.
- Practice good hand hygiene to stop spreading the virus.
How to Care for a Child with Chickenpox
- Keep the child comfortable and prevent scratching.
- Use antihistamines or calamine lotion for itching.
- Trim nails to avoid skin infections.
- Offer plenty of fluids and rest.
- If the child has a high fever or worsening symptoms, see a doctor.
When to Call the Doctor
- If your child has a high fever lasting more than 3 days
- If they have trouble drinking fluids or look dehydrated
- If the rash spreads rapidly or looks infected (red, swollen, oozing)
- If your child has breathing problems or unusual sleepiness
- If your child has a weakened immune system
Can Adults Get HFMD or Chickenpox?
Yes, adults can get both, but chickenpox is rarer now in adults because many have had it or the vaccine. HFMD is less common but possible.
FAQ
- Can HFMD and chickenpox happen at the same time?
It’s rare but possible. If you’re unsure, check with your doctor. - Is there a vaccine for HFMD?
No widely available vaccine exists yet, but chickenpox vaccines are common. - How long does chickenpox itch last?
Itching usually lasts until all blisters scab over, about 7 to 10 days. - Can my child go to school with HFMD or chickenpox?
No. Keep them home until fever is gone and blisters have healed or crusted. - Are HFMD or chickenpox dangerous?
Both are usually mild in healthy kids but watch for serious symptoms and see a doctor if worried.